Ctbp c-terminal binding protein
WebNov 2, 2024 · Intriguingly, we could find a putative CtBP interaction site, Pro-x-Asp-Leu motif 21, in the C-terminus of FoxO1 protein (Supplementary Fig. 2a, b) whereas the … WebApr 8, 2024 · First, the N-terminal domain is more variable, enabling KLFs to bind to a wide variety of genes as well as co-activators and co-suppressors, including C-terminal Binding Protein (CtBP) and Sin3A .
Ctbp c-terminal binding protein
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WebC-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene. Function. The CtBPs - CtBP1 and CtBP2 in mammals - are among … WebApr 9, 2024 · CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; NM_001377187.1 → NP_001364116.1 …
WebThe C-Terminal Binding Protein, or CtBP, is a conserved transcriptional corepressor protein and dehydrogenase expressed in both humans and … The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional corepressors. That is, regulatory proteins that bind to sequence-specific DNA-binding proteins and help turn genes off. CtBPs do this by recruiting histone modifying enzymes that add repressive histone marks and remove activating marks. CtBP proteins can also self-as…
WebC-terminal binding proteins (CtBPs) are cotranscriptional factors that play key roles in cell fate. We have previously shown that NAD (H) promotes the assembly of similar tetramers from either human CtBP1 and CtBP2 and that CtBP2 tetramer destabilizing mutants are defective for oncogenic activity. WebGene ID: 128937410, updated on 20-Mar-2024. Summary Other designations. C-terminal-binding protein 2
WebAccumulating evidence suggests that the corepressor C-terminal binding protein (CtBP) is an important regulator of hematopoietic homeostasis by virtue of its physical interaction with hematopoietic transcription factors …
WebMar 21, 2024 · CTBP2 (C-Terminal Binding Protein 2) is a Protein Coding gene. Diseases associated with CTBP2 include 46,Xy Sex Reversal 9 and Developmental And Epileptic Encephalopathy 75 . Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Regulation of activated PAK-2p34 by proteasome … toby weaverWebJan 29, 2009 · The CtBP family proteins are modulators of several essential cellular processes. Vertebrate genomes code for two related proteins, CtBP1 and CtBP2, whereas the invertebrate genomes code for a single protein. Vertebrate CtBP genes perform genetically related and unique functions during development. toby weaver salisbury mdWebSynonyms: CTBP1 phospho Ser422, p-CTBP1 Ser422, CtBP1 phospho S422, BARS, C terminal binding protein 1, CTBP, CTBP1, MGC104684, CTBP1_HUMAN, C-terminal … toby webbWebCorepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This … toby way tolworthWebApr 24, 2024 · A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. Genomics 47 , 294–299 (1998). penny\\u0027s from heavenWebJan 30, 2006 · MEQ sequence shows a consensus Pro-Leu-Asp-Leu-Ser (PLDLS) motif known to bind CtBP (C-terminal-binding protein), a highly conserved cellular factor with roles in the regulation of development, proliferation, and apoptosis. CtBP was initially identified as a cellular protein that interacts with the C terminus (amino acids 225–238) … penny\u0027s fried chickenWebApr 17, 2003 · The transcriptional co-repressor CtBP (C-terminal binding protein) is implicated in tumorigenesis because it is targeted by the adenovirus E1A protein during oncogenic transformation 1. Genetic ... toby web app