Ctgf growth factor
WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, … WebOct 26, 2024 · Connective tissue growth factor (CTGF), also known as CCN family protein 2 (CCN2), is composed of four domains, including insulin-like growth factor binding protein-like (IGFBP), von Willebrand factor type C repeat (VWC), thrombospondin type 1 repeat (TSP1), and C-terminal cystine-knot (CT) modules . It is a cysteine-rich …
Ctgf growth factor
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WebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it … WebNov 1, 2016 · Introduction. Connective tissue growth factor (CTGF/CCN2) is a secreted matricellular protein known to play important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, vascular differentiation, and myofibroblast formation, all of which can lead to tissue remodeling and changes in organ …
WebShowing of 1,925 Results for CTGF Search Time: 0 ms. Export Show: Symbol Description Category UniProt ID GIFtS GC id Score; 1: CCN2: Cellular Communication Network Factor 2 ... Cellular Communication Network Factor 2: Protein Coding: P29279: 53: GC06M131948: 35.24: 2: TGFB1: Transforming Growth Factor Beta 1: Protein Coding: … WebOct 4, 2012 · Background The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the pathogenesis of hepatitis C virus (HCV)-induced liver fibrosis remains unclear. Methods In the present study, we assessed …
CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor … See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. Ctgf-null mice also show defects in angiogenesis, with impaired interaction between endothelial cells and pericytes … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. … See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more WebConnective tissue growth factor (CTGF) is a secreted protein that binds to integrins, and regulates the invasiveness and metastasis of certain carcinoma cells. Here, we found that CTGF was upregulated in drug-resistant phenotype of human CRC cells. Overexpression of CTGF enhanced the resistance to 5-FU-induced cell apoptosis.
WebConnective tissue growth factor (CTGF) is a cysteine-rich protein the synthesis and secretion of which are hypothesized to be selectively regulated by activins and other …
WebJun 6, 2012 · Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are active in tumor-reactive stroma where CTGF is expressed. Other potential roles include prevention of hypoxia-induced apoptosis and … date of ratification of biak na batoWebAug 6, 2008 · Connective tissue growth factor (CTGF=CCN2), one of six members of cysteine-rich, secreted, heparin-binding proteins with a modular structure, is recognized as an important player in fibrogenic pathways as deduced from findings in non-hepatic tissues and emerging results from liver fibrosis. Collectively, the data show strongly increased ... bizhub 162 driver windows 10 64 bitWebPamrevlumab, our proprietary fully human antibody, targets connective tissue growth factor (CTGF), the central mediator of tissue remodeling and fibrosis. Pamrevlumab represents a potential treatment for a broad array of fibrotic and proliferative disorders that affect organ systems throughout the body. Pamrevlumab is in Phase 3 clinical studies for … date of readiness at the port of shipmentWebBy this attempt, we identified connective tissue growth factor (CTGF) as a novel factor highly expressed in infected hearts. Further investigations by quantitative reverse … date of receipt by the international bureauWebTissue proteome. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions … date of reagan assassination attemptWebAug 25, 2009 · Connective tissue growth factor (CTGF) is a secreted protein that is strongly induced in human and experimental heart failure. CTGF is said to be profibrotic; however, the precise function of CTGF is unclear. We generated transgenic mice and rats with cardiomyocyte-specific CTGF overexpression (CTGF-TG). To investigate CTGF as … bizhub 162 driver windows 10WebConnective Tissue Growth Factor (CTGF, CCN2, HCS24, IGFBP8, NOV2) is a heparin-binding glycoprotein with molecular weight of 36–38 KDa, composed of 343–349 amino acid residues and belonging to the CCN family. The CCN family of proteins is a complex family of multifunctional proteins containing six members designated CCN1 to CCN6. bizhub 163 toner