Des-γ-carboxy-prothrombin

Author: ilhz

August undefined, 2024

Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or mal… WebPatients were also more likely to have a fibrosis-4 (FIB-4) index > 3.25, Child–Pugh class A, and higher serum levels of alpha-fetoprotein and Des-γ-carboxy prothrombin (DCP). They were treated with sorafenib ( n = 275), lenvatinib ( n = 48), or ATZ/BV ( n = 36) as first-line therapy for advanced HCC.

Early decrease in α-fetoprotein, but not des-γ-carboxy prothrombin ...

WebNov 20, 2024 · A des-gamma-carboxy prothrombin (DCP) test may be used along with other tumor markers such as an alpha ... Bertino N, Boemi PM. 2010. Prognostic and … WebNov 19, 2000 · Des-γ-carboxy prothrombin (DCP) is a useful tumor marker for hepatocellular carcinoma (HCC). The conventional enzyme immunoassay (EIA) kit for DCP lacks adequate sensitivity to detect small … ont time

141325: Des-γ-carboxy Prothrombin (DCP) Labcorp

WebDec 20, 2014 · Purpose Alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) are prognostic factors for hepatocellular carcinoma (HCC). The impact of these tumor markers in recurrent HCC on the prognosis remains to be fully elucidated. Methods Two hundred and seventeen patients whose AFP and DCP levels were measured at … WebFeb 12, 2024 · Background: The role of des-γ-carboxy prothrombin (DCP) in patients undergoing radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) needs to be clarified. Materials and methods: 174 ... WebNov 29, 2015 · Determining the serum des-γ-carboxy-prothrombin (DCP) level is of great importance for the diagnosis of primary hepatocellular carcinoma (PHC). Although … iot chasity belt

A Systematic Review of Des-γ-Carboxy Prothrombin for the ... - LWW

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WebDes-gamma-carboxy prothrombin (DCP), also known as the protein induced by vitamin K absence or antagonist II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. DCP is a nonfunctional prothrombin resulting from a lack of carboxylation … WebDec 4, 2003 · Des-γ-carboxy prothrombin (DCP) is useful as a marker of hepatocellular carcinoma (HCC). However, because of its low sensitivity, DCP is not suitable for the … iot central transformationWebThe utility of AFP is limited by low sensitivity and specificity. 166 Many other serum biomarkers, such as des-γ-carboxy prothrombin, are becoming available, but their usefulness remains to be proved. Serum AFP level and US of the liver are recommended every 6 months for screening of patients at risk of developing HCC. 167. iot chaos

"WebObjective: To investigate the diagnostic value of des-γ-carboxy prothrombin (DCP) for recurrence in hepatocellular carcinoma (HCC) patients receiving precautionary sorafenib after curative liver resections. Methods: Eighty-five patients receiving curative hepatectomy and adjuvant sorafenib afterwards were enrolled. " - Des-γ-carboxy-prothrombin

Des-γ-carboxy-prothrombin

WebApr 24, 2002 · Serum des-γ-carboxy prothrombin (DCP) is a useful marker for the diagnosis of hepatocellular carcinoma (HCC), but the exact mechanism of its synthesis … WebBackground: The role of des-γ-carboxy prothrombin (DCP) in patients undergoing radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) needs to be clarified. Materials and methods: 174 HCC patients that underwent RFA were enrolled. We calculated the HLs of DCP from the available values before and on first day after ablation and ...

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WebFeb 12, 2024 · Background: The role of des-γ-carboxy prothrombin (DCP) in patients undergoing radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) needs to … WebDes-γ-carboxy prothrombin (DCP), also referred to as protein induced by vitamin K absence (PIVKA-II), is a nonfunctional precursor of prothrombin. 7 Prothrombin, …

WebDec 4, 2003 · Des-γ-carboxy prothrombin (DCP) is useful as a marker of hepatocellular carcinoma (HCC). However, because of its low sensitivity, DCP is not suitable for the initial detection of small HCC tumors. 1, 2 Recently, a sensitive method for serum DCP determination has been developed and reportedly is positive in 30–40% of patients with … WebDes-γ-carboxy prothrombin (DCP) is a prothrombin precursor produced in hepatocellular carcinoma (HCC). Because of deficiency of vitamin K or γ-glutamyl …

WebObjectives: The aim of this study was to investigate the relationships between early changes in the tumor markers α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), and antitumor response in the early period following administration of sorafenib in patients with advanced hepatocellular carcinoma (HCC). Methods: Forty-eight advanced HCC patients …

WebDes-γ-Carboxy Prothrombin. Serum concentrations of des-γ-carboxy prothrombin (DCP) (also known as prothrombin produced by vitamin K absence or antagonist II) are raised in most patients with HCC. 65 DCP is an abnormal prothrombin that is thought to result from a defect in the post-translational carboxylation of the prothrombin precursor …

WebZhu R, Yang J, Xu L, et al. Diagnostic performance of des-γ-carboxy prothrombin for hepatocellular carcinoma: a meta-analysis. Gastroenterol Res Pract. 2014;2014:529314. ... Post-ablation des-gamma-carboxy prothrombin level predicts prognosis in hepatitis B-related hepatocellular carcinoma. Liver Int. 2016;36(4):580–587. 27. ont tiscaliWebNov 29, 2015 · Determining the serum des-γ-carboxy-prothrombin (DCP) level is of great importance for the diagnosis of primary hepatocellular carcinoma (PHC). Although several studies have investigated the accuracy of diagnostic DCP tests for PHC, the results have been inconsistent. The aim of this study was to systematically evaluate DCP as a … ont to albWeb【友情提示】：产品价格与说明书请添加:，索要说明书；或者！产品名称 anti-gdf1/fitc,fitc标记的生长分化因子1抗体. 产品编号 byk-1794r-fitc. 英文名称 anti-gdf1/fitc iot characteristics javatpointWebMar 4, 2015 · Des-γ-carboxy prothrombin (DCP), also kn own as “ protein induced by vitamin K absenc e or antagonist-I I ” (PIVKA-II), is an abnorma l prothrombin that has be en widely used as a tumor ont to boiWebJan 26, 2007 · There is no established clinical role for the lens culinaris agglutinin-reactive fraction of α-fetoprotein (AFP-L3%) and des-γ-carboxy prothrombin (DCP) in the management of the U.S. hepatocellular carcinoma (HCC) patient population. In order to clarify the clinical usefulness and characteristics of AFP-L3% and DCP, a prospective … ont to ashevilleWebOct 31, 2000 · Serum concentrations of des-γ-carboxy prothrombin (DCP) from 91 patients with hepatocellular carcinoma (HCC) and 57 with cirrhosis (LC) are shown. There is a statistically significant difference between the serum concentrations of DCP in HCC (48.3 ± 24.3, mean ± standard deviation) and those in cirrhosis (20.3 ± 10.3), as determined by … ont to bdlWebNov 15, 2024 · Des-γ-carboxy-prothrombin (DCP) is an abnormal prothrombin in which one or more glutamic acid residues of the Gla domain are not fully carboxylated to gamma-carboxylated glutamate (Gla) in its … ont to atl direct