WebTo capture early changes in RNA transcription, JEKO1 and MAVER were treated for 6 hr with or without the inhibitors (0.4 uM for ibrutinib and 1.5 uM for selinexor) with three biological triplicates. Cells were harvested and subjected to RNA sequencing and diffrences in biological pathway perturvation were analyzed using GSEA. Web26 giu 2024 · Background The more selective second-generation BTK inhibitors (BTKi) Acalabrutinib and Zanubrutinib and the first-generation BTKi Ibrutinib are highlighted by their clinical effectiveness in mantle cell lymphoma (MCL), however, similarities and differences of their biological and molecular effects on anti-survival of MCL cells induced by these BTKi …
Targeting MYC-Driven B-Cell Lymphoma By Inhibition of the …
WebFigure Legend Snippet: CBL0137 inhibits B-NHL cell proliferation by inducing cell cycle arrest and promoting apoptosis. A Cell viability of B-NHL cells treated with various concentrations of CBL0137 for 24 h was measured by CCK-8 assay. B B-NHL cells were treated with 0.5 μM, 1.0 μM, 1.5 μM, 2.0 μM CBL0137, and 2.0 μM doxorubicin for 24 h, … WebDSMZ Cell Culture Data: Morphology: round single cells growing in suspension; image; image. Medium: 80% RPMI 1640 + 20% h.i. FBS. Subculture: seed out at ca. 0.5 x 10 6 … fleishman is in trouble saison 1 streaming
AID 528453 - Inhibition of CDK4 in human Jeko1 cells assessed as ...
Web29 nov 2024 · Therefore, we deleted DOT1L using CRISPR/Cas9 in B-cell lymphoma cell lines and assessed the effect on proliferation using competitive-proliferation assays. We observed that DOT1L-deletion progressively diminished the relative growth of anti-DOT1L sgRNA-expressing P493-6 and Jeko1 cells compared to non-targeted cells in vitro. WebDisruption of CD31 upregulation in JEKO1-CD31DOWN clonal cells was associated with impaired engraftment and retarded growth of the corresponding MCL xenografts (Figure 3(A)). Engraftment was detected only in 2 out of 8 JEKO1-CD31DOWN-injected mice with the two resulting xenografts growing slower as compared to controls. Web"Jeko1;人套细胞淋巴瘤稳定克隆细胞 配套完全培养基 BS-C01106851 背景信息：一位套细胞淋巴瘤患者的巨细胞变种显示白血病转变，从其外周血单核细胞出发建立了MCL细胞株JeKo-1。 JeKo-1细胞EB病毒阴性，并表达一种B细胞表型的IgM。 细胞过表达cyclin fleishman is in trouble subtitulos