The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule: phosphatidylcholine + H2O = 1 … See more Phospholipases A2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A2. Other families include Ca independent … See more The suggested catalytic mechanism of pancreatic sPLA2 is initiated by a His-48/Asp-99/calcium complex within the active site. The … See more Due to the importance of PLA2 in inflammatory responses, regulation of the enzyme is essential. cPLA2 is regulated by phosphorylation and calcium concentrations. … See more Human phospholipase A2 isozymes include: • Group I: PLA2G1B • Group II: PLA2G2A, PLA2G2C See more PLA2 action can release histamine from rat peritoneal mast cells. It also causes histamine release in human basophils. See more In normal brain cells, PLA2 regulation accounts for a balance between arachidonic acid's conversion into proinflammatory mediators and its reincorporation into the membrane. In the absence of strict regulation of PLA2 activity, a … See more • Paul Sigler See more WebPreferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:7794891, ... The disease is caused by variants affecting the gene represented in this entry; Description. An autosomal recessive disorder characterized by recurrent gastrointestinal mucosal ulcers ...
PLA2G2A (human) Gene Target - PubChem
WebMar 17, 2024 · The PLA2G6 gene encodes a group of VIA calcium-independent phospholipase A2 (iPLA2β) enzymes, which participate in various cellular functions, including phospholipid metabolism, membrane homeostasis, calcium signaling, apoptosis, and mitochondrial function. Thus, these functions could be perturbed by PLA2G6 gene … WebPLA2G2A (human) Gene Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National … cibc rocky mountain house
PLA2-ALPHA Phospholipase A2 family protein
WebCadmium is a heavy metal that is known to cause toxicity to cells and, at low concentrations, can initiate apoptosis. This study was undertaken with the aim of defining the role of phospholipase C (P WebSullivan CP, Seidl SE, Rich CB et al Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J Biol Chem 285:565–575 WebGene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. LOC119581056 cytosolic phospholipase A2-like [ (black tiger shrimp)] Gene ID: 119581056, updated on 4-Feb-2024. Summary Other designations. LOW QUALITY PROTEIN: cytosolic phospholipase A2-like ... cibc rougemount