Phospholipase a2 gene

The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule: phosphatidylcholine + H2O = 1 … See more Phospholipases A2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A2. Other families include Ca independent … See more The suggested catalytic mechanism of pancreatic sPLA2 is initiated by a His-48/Asp-99/calcium complex within the active site. The … See more Due to the importance of PLA2 in inflammatory responses, regulation of the enzyme is essential. cPLA2 is regulated by phosphorylation and calcium concentrations. … See more Human phospholipase A2 isozymes include: • Group I: PLA2G1B • Group II: PLA2G2A, PLA2G2C See more PLA2 action can release histamine from rat peritoneal mast cells. It also causes histamine release in human basophils. See more In normal brain cells, PLA2 regulation accounts for a balance between arachidonic acid's conversion into proinflammatory mediators and its reincorporation into the membrane. In the absence of strict regulation of PLA2 activity, a … See more • Paul Sigler See more WebPreferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:7794891, ... The disease is caused by variants affecting the gene represented in this entry; Description. An autosomal recessive disorder characterized by recurrent gastrointestinal mucosal ulcers ...

PLA2G2A (human) Gene Target - PubChem

WebMar 17, 2024 · The PLA2G6 gene encodes a group of VIA calcium-independent phospholipase A2 (iPLA2β) enzymes, which participate in various cellular functions, including phospholipid metabolism, membrane homeostasis, calcium signaling, apoptosis, and mitochondrial function. Thus, these functions could be perturbed by PLA2G6 gene … WebPLA2G2A (human) Gene Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National … cibc rocky mountain house https://alltorqueperformance.com

PLA2-ALPHA Phospholipase A2 family protein

WebCadmium is a heavy metal that is known to cause toxicity to cells and, at low concentrations, can initiate apoptosis. This study was undertaken with the aim of defining the role of phospholipase C (P WebSullivan CP, Seidl SE, Rich CB et al Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J Biol Chem 285:565–575 WebGene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. LOC119581056 cytosolic phospholipase A2-like [ (black tiger shrimp)] Gene ID: 119581056, updated on 4-Feb-2024. Summary Other designations. LOW QUALITY PROTEIN: cytosolic phospholipase A2-like ... cibc rougemount

119581056 - Gene ResultLOC119581056 cytosolic phospholipase A2 …

Category:Pla2g4c (phospholipase A2 group IVC) - Rat Genome Database

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Phospholipase a2 gene

Pla2g4c (phospholipase A2 group IVC) - Rat Genome Database

WebMar 28, 2024 · In a Serbian brother and sister with GURDP, Brooke et al. (2014) identified a homozygous 4-bp deletion in the PLA2G4A gene ( 600522.0004 ). The mutation, which … WebPhospholipase A2 Gene PLA2G1B Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 148 Protein existence Evidence at protein level Annotation …

Phospholipase a2 gene

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WebSep 13, 2024 · To this regard, various host phospholipase A2 enzymes have been described to specifically cleave and remove peroxidised phospholipids from membranes [60–62]. To address this hypothesis, we performed a redox phospholipidomic approach to determine if ExoU could interfere with the endogenous levels of peroxidised phospholipids ( Figs … WebThe Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men. J Clin Endocrinol Metab. 2006;91(9):3521–3527. 54. Xu L, Zhou J, Huang S, et al. An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A2 and ...

WebPhospholipase A2: hydrolyzes the glycerol-fatty acid ester in position 2. ... This gene encodes a phospholipase A 2 enzyme that plays a crucial role in mitochondrial membrane … WebMar 8, 2024 · The sequences of mammalian phospholipases were collected in the database UniProt by entering the gene names PLA2G1B and PLA2G2A, considering only the ten curated entries for PLA2G1B, and the five curated entries plus five other entries in the case of PLA2G2A. ... The phospholipase A2 superfamily and its group numbering system. …

WebDec 18, 2024 · Phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN) includes a series of neurodegenerative diseases that result from the mutations in PLA2G6. PLAN has genetic and clinical heterogeneity, with different mutation sites, mutation types and ethnicities and its clinical phenotype is different. WebMar 13, 2024 · In this study, the function of the patatin-like phospholipase gene in V. dahliae (VdPLP, VDAG_00942) is characterized by generating gene knockout and complementary mutants. ... Percudani, R.; Bonfante, P.; Ottonello, S. A nutrient-regulated, dual localization phospholipase A2 in the symbiotic fungus Tuber borchii. EMBO J. 2001, 20, 5079–5090 ...

WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic phospholipase A2 …

WebThe phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids ( Chiba et al., 2004 ). Cloning and Expression dg heightWebHas phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid ( By similarity ). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion ( By similarity ). dghe modulesWebENCODES a protein that exhibits calcium-independent phospholipase A2 activity (ortholog); lysophospholipase activity (ortholog); O-acyltransferase activity (ortholog); INVOLVED IN glycerophospholipid catabolic process (ortholog); lipid droplet formation (ortholog); phosphatidylcholine acyl-chain remodeling (ortholog); ASSOCIATED WITH genetic disease … dgh emergencycibc rocky mountain house hoursWebSpecifically, the A2 phospholipase produced from the PLA2G6 gene, sometimes called PLA2 group VI, helps to regulate the levels of a compound called phosphatidylcholine, which is … dghe gatewayWebENCODES a protein that exhibits calcium-independent phospholipase A2 activity (ortholog); lysophospholipase activity (ortholog); O-acyltransferase activity (ortholog); INVOLVED IN … dghennessee gmail.comWebThis gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. cibc royal oak